The intrusive neighbor with deep ties to the house's history. The Murder House - American Horror Story

The fictional "Murder House" was inspired by several real-world elements:

The house itself seems to "want" things, often driving residents to madness or violence. Historical Inspiration The intrusive neighbor with deep ties to the house's history

The Murder House remains the most iconic location in the franchise. It has reappeared in later seasons, most notably:

The real location used for filming in Arlington Heights, LA. The Murder House - American Horror Story

Spirits can choose to be visible or invisible to the living.

The resident housekeeper who appears differently to men and women. The House Rules