In Episode 6 of Manifest , titled the mystery shifts from individual "Callings" to a conspiracy involving the missing passengers of Flight 828. This episode is a turning point where Ben Stone realizes that being a passenger makes him part of a larger, more dangerous experiment. The Mystery of the "Fever"

Every time the scientists shock Marko's brain or subject him to stimuli, Cal reacts in the hospital with the same physical trauma. Cal has become a human radar for the suffering of his fellow passengers. Michaela’s Investigation

Ben teams up with and Olive to track down where these 11 passengers were taken. They realize the government didn't just lose track of them; they were spirited away by a mysterious entity known as Unified Dynamic Systems (UDS) .

Ben discovers that UDS is conducting painful experiments on these "forgotten" passengers to test their connection to the Callings.