The model categorizes patients into three risk groups based on how many of these four parameters they meet: Risk Subgroup Criteria (Parameters met) Progression-Free Survival (PFS) Overall Survival (OS) 0 parameters Intermediate 1 or 2 parameters High-Risk 3 or more parameters
Documented meningeal lymphomatosis (spread to the brain or spinal cord membranes).
While the International Prognostic Index (IPI) is the standard, KBMP4 provides a more granular look at aggressive "Double-Hit" or "Double-Expression" lymphomas.
High proliferation index (Ki67 ≥ 70%) on immunohistochemistry. B (Bulky): Physical presence of a tumor mass ≥ 7.5 cm.
It was designed to offer better accuracy than traditional metrics by combining cellular biomarkers with imaging data and physical disease characteristics. The Components of KBMP4
The model is a clinical scoring system used to predict the survival and prognosis of patients with de novo Diffuse Large B-cell Lymphoma (DLBCL) .