The solute must not undergo association (clumping) or dissociation (breaking into ions) in either solvent. If the solute reacts with a solvent or ionizes, the formula must be modified to account for these chemical changes. Practical Applications
The two solvents must not dissolve in one another. distribution law
If the distribution coefficient and the solubility of a solute in one solvent are known, its solubility in the second solvent can be calculated. The solute must not undergo association (clumping) or