Diana-131-042 Official

: DIANA is a "top-down" algorithm. It starts with one large cluster containing all data points and recursively splits them into smaller, more specific clusters until each point is in its own group.

: It is preferred for large datasets where researchers want to see the broad structure of the data before diving into smaller sub-groups. diana-131-042

: In the context of bioinformatics (like the DIANA-miRPath platform), this method helps identify clusters of miRNAs that share similar functional targets, such as those involved in KEGG or REACTOME pathways. : DIANA is a "top-down" algorithm