Daniella Aire Direct

A helpful paper would explain how the AIRE gene functions as a transcriptional regulator in the thymus. It helps "train" the immune system by expressing proteins normally found only in peripheral tissues (like the insulin from the pancreas) within the thymus. This allows the immune system to identify and eliminate self-reactive T-cells before they can cause harm. 2. Autoimmunity and Genetic Variants

: Investigating how AIRE-dependent development of specific "early life" Tregs protects tissues from attack, which could lead to new immunotherapies for T1D and other autoimmune conditions. daniella aire

Editorial: The Role of Aire, microRNAs and Cell ... - PMC - NIH A helpful paper would explain how the AIRE

: Understanding why AIRE-deficient individuals develop specific organ-restricted autoimmune diseases. 3. Emerging Therapeutic Perspectives daniella aire